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Tuas South is an industrial area in the south-westernmost region of Singapore.

It is an entirely reclaimed land south-west off Tuas Crescent and Tuas South Avenue 5.

It is home to some of the world's largest pharmaceutical companies like GlaxoSmithKline and Pfizer. The Tuas Marine Transfer Station located on the western shores will transport the island's incinerated wastes to Pulau Semakau for landfills. Furthermore, the world's largest tunnel for storage of oil is being built in the south of extension. Two of the four incinerators in Singapore are also located in Tuas South. Currently land reclamation is being carried out in the Southern side of Tuas South in which it will stretch near to the sea border with Indonesia and it will be the southernmost point of Singapore mainland.

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